Interfacing Microfluidic Handling with Spectroscopic Detection for Real‐Life Applications via the Lab‐on‐Valve Platform: A Review

Abstract

One of the current needs within the analytical spectrometric community is the development of straightforward and cost‐effective, yet rugged, sample processing procedures aimed at precluding both spectroscopic and nonspectroscopic matrix interferences while fostering concomitant sample enrichment. Illustrated via selected representative examples, this review presents and discusses the current state of the art in implementing miniaturised and automated sample treatments for environmental and biochemical assays via microfluidic systems exploiting the lab‐on‐valve (LOV) platform in hyphenation with syringe pump propelling devices as a front end to a plethora of spectroscopic detection schemes including ultraviolet‐visible (UV‐Vis) spectrometry, spectrofluorimetry, chemiluminescence, atomic absorption spectrometry (AAS), atomic flourescence spectrometry (AFS), and inductively coupled plasma‐atomic emission spectrometry/mass spectrometry (ICP‐AES/MS). In contrast to lab‐on‐a‐chip units, the versatile configuration of the micromachined LOV readily facilitates the implementation of on‐line unit operations at will encompassing not merely the introduction of minute, well‐defined volumes of sample followed by chemical derivatization, but the potential for accommodation of solid‐phase extraction, hydride/vapor generation, precipitation/coprecipitation, and bead injection protocols with no need for chip redesign.     

退火对FeMn钉扎自旋阀性质的影响

通过对退火后FeMn钉扎自旋阀磁性的研究表明,真空退火对自旋阀的性质有影响.低于200℃的退火能有效的提高钉扎场;退火温度高于200℃时,自旋阀的钉扎场要下降,其他性能也恶化;在300℃时,钉扎场降为零,giantmagnetoresistance(GMR)现象消失.俄歇电子能谱仪(AES)的结果表明,在自旋阀多层膜中存在着晶界扩散 关键词： 真空退火 自旋阀 晶界扩散     

Correlation between the exchange bias and the degree of ordering of antiferromagnetic layer in PtMn/Co–Fe bilayers

Correlation between the unidirectional anisotropy constant, J_K, and the degree of ordering of PtMn layer was investigated for Pt₅₅Mn₄₅/Co₉₀Fe₁₀ bilayer, as a function of the annealing time and the PtMn layer thickness, d_AF. As a result, we found the linear relations between J_K and the degree of ordering, f_FCT·S, in the cases of the bilayers with d_AF=5–50 nm. From the extrapolation of the linear relations to f_FCT·S=1, meaning the perfect ordering of PtMn layer, we obtained the attainable value of J_K and the intrinsic critical thickness of the PtMn layer to be 0.26 erg/cm² and 6 nm, respectively.     

Spin-polarized electronic reflections at metal–oxide interfaces

The ultra-thin oxide tunnel barrier employed in magnetic tunnel junctions stack has to be of very high quality in terms of large scale homogeneity of its thickness and height parameters. For controlling precisely oxidation kinetic, we used spin valves as an oxidation progress probe. By measuring the magnetoresistance effect versus the oxidation time we are able to detect under- or over-oxidation of the metallic material. This technique consists of analysing the ability of spin-dependent electron scattering at metal/oxide interfaces.     

柔性瓣架对生物心脏瓣膜应力的影响

采用非线性大变形超参数八结点板壳元，针对用猪主动脉瓣制成的人工心瓣所用的瓣架材料，形状，侧边高度等对其应力的影响进行数值模拟分析，其中瓣叶的几何形式保持不变。结果表明：弹性瓣架存在一个合适的弹性模量范围，能使瓣叶的最大应力降低较明显；对同一种瓣叶和具有相同弹性模量的瓣架而言、使瓣架立柱顶端产生位移最大的瓣架形状，往往亦是使瓣叶最大应力降低２的最明显的瓣架形状。     

An experimental study of the combustion characteristics in SCCI and CAI based on direct-injection gasoline engine

Emissions remain a critical issue affecting engine design and operation, while energy conservation is becoming increasingly important. One approach to favorably address these issues is to achieve homogeneous charge combustion and stratified charge combustion at lower peak temperatures with a variable compression ratio, a variable intake temperature and a trapped rate of the EGR using NVO (negative valve overlap). This experiment was attempted to investigate the origins of these lower temperature auto-ignition phenomena with SCCI and CAI using gasoline fuel. In case of SCCI, the combustion and emission characteristics of gasoline-fueled stratified-charge compression ignition (SCCI) engine according to intake temperature and compression ratio was examined. We investigated the effects of air–fuel ratio, residual EGR rate and injection timing on the CAI combustion area. In addition, the effect of injection timing on combustion factors such as the start of combustion, its duration and its heat release rate was also investigated.     

压缩机排气舌簧阀的计算模型及其动态分析

本文对具有面接触式升程限制器(即背板)的排气舌簧阀提出一个计算模型和相应的分析方法;据此可确定阀片的振型、固有频率、瞬时位移、瞬时速度和加速度、动态应力等.计算结果与实验结果符合良好.本文方法也可用于分析某些增压器、真空泵等设备中的阀片.     

磁流变阀控制行波壁的实验研究

对于在流体中运行的航行器,为了降低能量消耗和提高运行速度,减少流体的阻力至关重要。由于理论上可以将阻力降为零,行波壁减阻受到了广泛关注。但是目前所有的行波壁都是使用复杂的机械装置实现,因为这些机构体积大,耗能多而且不能适应不同的航行器的外形表面,所以难以应用于实际的航行器。本文中设计并制造了使用磁流变阀控制的二维行波壁,并且将样机在水槽中进行了实验研究。发现当C/U为0.309时,在波谷处可以形成稳定的涡。这种系统结构简单并可以布置在任意形状的表面上。该研究为行波壁在实际航行器上的应用提供了可行性。     

Normal human mitral valve proteome: A preliminary investigation by gel‐based and gel‐free proteomic approaches

The mitral valve is a highly complex structure which regulates blood flow from the left atrium to the left ventricle (LV) avoiding a significant forward gradient during diastole or regurgitation during systole. The integrity of the mitral valve is also essential for the maintenance of normal LV size, geometry, and function. Significant advances in the comprehension of the biological, functional, and mechanical behavior of the mitral valve have recently been made. However, current knowledge of protein components in the normal human mitral valve is still limited and complicated by the low cellularity of this tissue and the presence of high abundant proteins from the extracellular matrix. We employed here an integrated proteomic approach to analyse the protein composition of the normal human mitral valve and reported confident identification of 422 proteins, some of which have not been previously described in this tissue. In particular, we described the ability of pre‐MS separation technique based on liquid‐phase IEF and SDS‐PAGE to identify the largest number of proteins. We also demonstrated that some of these proteins, e.g. αB‐Crystallin, septin‐11, four‐and‐a‐half LIM domains protein 1, and dermatopontin, are synthesised by interstitial cells isolated from human mitral valves. These initial results provide a valuable basis for future studies aimed at analysing in depth the mitral valve protein composition and at investigating potential pathogenetic molecular mechanisms. Data are available via ProteomeXchange with identifier PXD004397.     

核级阀门唇焊焊缝熔深的超声检测方法*

核电阀体唇焊焊缝熔深不足可能导致其在服役期内无预期断裂,由此引起的流质泄露将引起严重的安全事故。因此,极有必要在阀体焊接完成后进行熔深测量以保证足够的焊缝强度。本研究针对阀体唇焊缝粗糙余高曲面声学耦合差、熔深测量难的问题,提出基于喷水式超声聚焦检测技术的唇焊焊缝熔深测量方法。首先,根据核电阀体唇焊焊缝结构特点提出唇焊熔深的超声聚焦测量方法;其次,通过构建检测过程的有限元模型分析焊缝余高曲率对声场聚焦能力的影响,给出余高曲率各异的焊缝检测时的水距修正方法,以便在预定熔深范围内形成高能聚焦声场;最后,分析和提取与唇焊结构相关的检测信号特征,结合金相分析方法修正声速。研究结果显示：通过水距修正可改善焊缝曲率半径变化对聚焦声场的不利影响,曲率半径28.5 mm时焦区声压幅度仅下降11%,基于特征脉冲时间间隔及声速修正可测定焊缝熔深;与金相试验对比,绝对误差小于0.06 mm,满足核电阀门唇焊焊缝熔深测量的需求。